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- DTN 040: Scientists Restore Mobility in a Parkinson's Patient
DTN 040: Scientists Restore Mobility in a Parkinson's Patient
Plus: First successful face and whole eye transplant, SpaceX prepares for second Starship flight this week, first US direct-air carbon capture facility, and more.
On Funga’s approach to machine learning and mushrooms: “It starts with soil samples and large amounts of data from DNA sequencing. In the southeast US we have over 600 soil samples and developed a broad forest soil biodiversity database. We’re linking that database to elevation, climate, and other abiotic factors that are important to predict our desired restored soil profile. Machine learning is used to analyze the massive amount of data and over time through continued soil sampling and monitoring of all our landowner project sites, we fine tune and improve our fungal inoculations. We then use the soil inoculant to apply to tree seedlings.”
How fungal rewilding accelerates soil restoration and forest resiliency: “The results are fast—you’ll likely see them in the first year. Our CEO and founder, Colin Averill, was a co-author of a global meta analysis that aggregated data across 80 sites and found wild fungal microbiome restoration can accelerate plant growth and carbon capture across multiple ecosystems by an average of 64%. We have a tool in our toolkit that can have an outsized impact and it is right under our feet. From a climate perspective, global restoration is a gigaton solution available today. For the first time we have the tools, we have the technology, and we have more and more ambition to go out there and make a real difference in the landscape across the globe with technology like this.”
The Big Picture
“People with late-stage Parkinson’s disease (PD) often suffer from debilitating locomotor deficits that are resistant to currently available therapies. To alleviate these deficits, we developed a neuroprosthesis operating in closed loop that targets the dorsal root entry zones innervating lumbosacral segments to reproduce the natural spatiotemporal activation of the lumbosacral spinal cord during walking. We first developed this neuroprosthesis in a non-human primate model that replicates locomotor deficits due to PD. This neuroprosthesis not only alleviated locomotor deficits but also restored skilled walking in this model. We then implanted the neuroprosthesis in a 62-year-old male with a 30-year history of PD who presented with severe gait impairments and frequent falls that were medically refractory to currently available therapies. We found that the neuroprosthesis interacted synergistically with deep brain stimulation of the subthalamic nucleus and dopaminergic replacement therapies to alleviate asymmetry and promote longer steps, improve balance and reduce freezing of gait. This neuroprosthesis opens new perspectives to reduce the severity of locomotor deficits in people with PD.” (Nature)
“The US has approved a single design for a small, modular nuclear reactor developed by the company NuScale Power. The government's Idaho National Lab was working to help construct the first NuScale installation, the Carbon Free Power Project. Under the plan, the national lab would maintain a few of the first reactors at the site, and a number of nearby utilities would purchase power from the remaining ones. With the price of renewables dropping precipitously, however, the project's economics have worsened. Some of the initial backers started pulling out of the project earlier in the decade, although the numbers continued to fluctuate in the ensuing years. The final straw came on Wednesday, when NuScale and the primary utility partner, Utah Associated Municipal Power Systems, announced that the Carbon Free Power Project did not have enough utility partners at a planned checkpoint and, given that uncertainty, would be shut down.” (Ars Technica)
“A bipartisan group of 18 lawmakers in the US Congress have recently amplified a request to the White House and the Secretary of Commerce to place restrictions on Americans working with RISC-V (see also the initial request from the Senate) in order to prevent China from gaining dominance in CPU technology. Any restrictions placed on US persons sharing RISC-V technology would only serve to diminish America’s role as a technological leader. Over-broad restrictions could deprive educators of a popular tool used to teach students about computers on American campuses, for fear of also accidentally teaching to an embargoed entity. And even narrow restrictions on RISC-V could deprive US tech companies with any potential exposure to the Chinese market of access to a cost-effective, high-performance CPU technology, forcing them to pay royalties to the incumbent near-monopoly provider, ARM Holdings plc – a company that isn’t American. This weakens American competitiveness and ultimately harms the US’s best interests.” (Bunnie Studios)
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Deep Tech News
Israel downing Houthi missile is first instance of space warfare
US Air Force's new B-21 Raider "flying wing" bomber takes first flight
SpaceX will launch the X-37B on a Falcon Heavy rocket Dec. 7
Impending sale of scientifically critical helium sparks worries
Doctors Complete First Successful Face and Whole-Eye Transplant
U.S. Hits Carbon Tech Milestone with First Direct-Air Capture Facility
The US and 30 Other Nations Agree to Set Guardrails for Military AI
Meta will start requiring disclosures for political ads manipulated with AI
JPEG of the Week
A sounding rocket launched from Poker Flat Research Range in Fairbanks, Alaska, Nov. 8, 2023, carrying NASA's Goddard Space Flight Center's DISSIPATION mission.
The rocket launched into aurora and successfully captured data to understand how auroras heat the atmosphere and cause high-altitude winds. The teams continue to support a second sounding rocket launch for BEAM-PIE, a mission for Los Alamos National Laboratory that will use an electron beam to create radio waves, measuring how atmospheric conditions modulate them. The data is key to interpreting measurements from many other missions. (NASA)
Peer Review
Silver Nanowire Networks to Overdrive AI Acceleration, Reservoir Computing
Cell Reprogramming for Regeneration and Repair of the Nervous System
Avalanche of published academic articles could erode trust in science
Physicists trap electrons in a 3D crystal for the first time
Photonics team develops high-performance ultrafast lasers that fit on a fingertip
Funding x M&A
Aleph Alpha raises $500m Series B in one of Europe’s largest AI rounds ever
Congruent starts raising fresh $250M early-stage climate tech fund
RNA editing startup Ascidian Therapeutics raised a $40M Series A extension
Niron Magnetics, a startup manufacturing rare earth-free permanent magnets, raised a $33M round (Disclosure: Niron is a Haus client)
Ghost Autonomy, an autonomous driving startup, received a $5M investment from the OpenAI Startup Fund
Renewable energy infrastructure company Talus Renewables raised a $22M Series A
Princeton NuEnergy, a startup focused on recycling and commercializing lithium-ion battery materials, raised a $16M Series A
HeartBeat.bio, a biotech startup providing a human organoid and AI-supported drug discovery platform for heart disease, raised a $4.8M pre-series A
Hyperspectral imagery startup Kuva Space raised a $17.6M Series A
Miscellanea
Transmitting Power from Star to Star with Gravitational Lensing / Overheating datacenter stopped 2.5M bank transactions / Oracle Employee Helped Cocaine Dealers Hide $54M in Crypto, DOJ Says / How one patient found errors in the algorithm making transplant decisions / A robot in South Korea mistook a man for a box of vegetables and killed him / The hijacking of $339,000 worth of rare Japanese KitKats / Iceland declares state of emergency over volcanic eruption threat / Trading bot that buys stocks bought by politicians is up 20% since May 2022 / Over the past six years, governments proposed launching more than 1 million satellites / Everything announced at OpenAI’s first developer event
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